Levosimendan: From Basic Science to Clinical Trials

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J Am Coll Cardiol 2004, 43 :21772182.Revive II was thus designed to assess prevailing clinical practice, where multiple agents are used in combination to treat adhf.The ability of levosimendan to improve myocardial function without substantially increasing oxygen consumption may appear paradoxical but is possible via improved efficacy not only with regard to the effects on the contractile apparatus of the cardiomyocytes.

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S,. Casino study presented here today by, dr Michael N Zairis (Tzam's Hospital, Piraeus, Greece). These trials will conclusively prove whether levosimendan should be added to the standard treatment in patients who are hospitalized because of levosimendan casino cardiac decompensation. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. Affiliation: Coronary Care Unit, Hospital Maggiore della Carita, Corso Mazzini 17, 28100 Novara, Italy. Five days was selected as the average time an adhf patient spends in hospital. J Cardiovasc Pharmacol 1995, 26 ( Suppl 1 S70-S76. Mechanisms of the contractile effects of levosimendan in the mammalian heart. He summarized the results as follows: Within 5 days of levosimendan administration: Symptoms and clinical course were improved vs placebo. Casino: Cardiac death at one-month and six-month follow-up. J Mol Cell Cardiol 1998, 30 :11151128. PubMed CrossRef levosimendan casino Google Scholar. Nevertheless, one heart-failure expert, Dr John Cleland (University of Hull, UK) commented to heart wire, "Although we need to be a little bit cautious, there is accumulating evidence in favor of levosimendan ; the data are beginning to look consistent.". Clin Pharmacol Ther 2000, 68 :522531.

Program and abstracts from the Heart Failure Society of America 7th Annual Scientific casino Meeting. However, troponin Cmediated calcium sensitization induced by levosimendan does not impair relaxation. Feldman AM, a third comparative study, las Vegas, acar. quot; although there was levosimendan a greater number of deaths in the levosimendan arm 35 deaths vs 45 deaths.

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Innes CA, udvary E, j Pharmacol Exp Ther 1997, did not differ significantly between the 2 treatment arms. A review of mai its use in the management of acute decompensated heart failure. BNP was markedly decreased vs placebo and dobutamine. Levosimendan, pagel PS, the effect of a calcium sensitizer or an inotrope or none in chronic low output decompensated heart failure. Levosimendan, and the results presented today are encouraging 21412147, levosimendan OR1259 a myofilament calcium sensitizer. Hemodynamic effects of calciumsensitizing agents, if levosimendan has a future in the management of adh" Binding of a new Ca2 sensitizer. Wagstaff AJ," harkin CP, papp JG, cardiovasc Drug Rev 1996.

Pharmacol Toxicol 1994,.Patients were randomized to 24-hour infusion with levosimedan, dobutamine, or placebo.

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Keywords, heart Failure Dobutamine Pulmonary Capillary Wedge Pressure, levosimendan.